The primary pathogenesis of IBM is not determined, although in IBM the aggregated proteins are in muscle tissue, many such as tau, alpha synuclein, TDP-43, beta amyloid and the prion protein are implicated in neurodegeneration. It is possible that the defective processes that lead to the formation of these abnormal protein deposits are likely to have important implications for many neurological disorders.
Link: http://www.cnmd.ac.uk/documents/the-international-ibm-consortium-genetic-studyYear Trial Ends: 2027